Prevalence of chronic liver disease in non-HCV and HBV in our population:
Prevalence of chronic liver disease in non-HCV and HBV in our population: Authors: DRghulamrasoolbhurgri, Shamim-ur-Rehman, Bilawal anisrehman. Abstract: Liver disease is the function of damaged hapetocytes may cause hepatocellular necrosis, fibrosis and regeneration with formation of nodules. In our study, a group of patients who are negative for both viral markers was, there were more women who have chronic liver disease. This group should be further considered for well-defined but rare causes of chronic liver disease. Keywords: hepatitis, liver disease, chronic liver disease, hepatitis C, hepatitis B, cirrohosis.
Prevalence of chronic liver disease in non-HCV and HBV in our population:
Authors:DRghulamrasoolbhurgri,shamim-ur-rehman,bilawal, anisrehman.
SUMMARY:
Diseases of the liver are damaged function hapetocytes may cause hepatocellular necrosis, fibrosis and regeneration with formation of nodules.
In our study, a group of patients who are negative for both viral markers was, there were more women who have chronic liver disease. This group should be further considered for well-defined but rare causes of chronic liver disease.
Keywords: hepatitis, liver disease, chronic liver disease, hepatitis C, hepatitis B, cirrohosis.
INTRODUCTION:
INTRODUCTION:
Chronic liver disease, liver damage in the process of slow and sustained over a long period. This means that there is so slow acting poison to a human body healthy. It is characterized by replacement of liver tissue by fibrous scar tissue and regenerative nodes (nodes that occurs after injury in which the process is regenerated tissues. There is already a progressive loss of liver cirrhosis due alcoholism, but our population is prohibited by individuals based on religion, poverty and social customs, hepatitis C, hepatitis B are the main tasks of this dangerous disease in our population .
Basic structure of the liver:
“The liver is the largest gland in the body, weighing about 1. 4 P g in an adult. It was under the diaphragm into the abdominal cavity and is held in place by several ligaments. It is reddish brown and consist of four anatomical lobes. If it can be viewed from the front left and right lobes are dominant and which are seen separated from the falciform ligament. in a depression on the posterior surface of the liver gallbladder, pear-shaped bag that stores bile synthesis by the position of the liver. The liver performs many metabolic functions. It has the ability to store recyclable materials such as nutrients and metabolites, but it fails or to the detoxification of harmful substances to be slower and less harmful “(Dr. viva Rolfe 2004)
“Liver, weighing about 1. 2-1. K 6 g moved many functions to maintain good health. It is on the right side of the body under the lower ribs and is divided into four lobes of varying size. Two large vessels carry blood to the liver, the hepatic artery in the heart and carries blood rich in nutrients absorbed from the intestine. These vessels are divided in vessels smaller and smaller and end in the capillaries. Each lobe is made hepatocytes, add or remove content from this. The blood then leaves the liver through the hepatic vein, back in the heart and is ready to be pumped to the rest of the blood.
Are the most important functions of the liver,
“The liver is an organ in vertebrates, including humans. It plays a significant metabolism and has a number of functions in the body, including detoxification, glucagon-storage and plasma protein sythesis. IT also produces acids bile, which is important for digestion. In addition, from the liver or liver from the Greek word for liver, Hep. hepatocytes play key role in.
Physiological functions of the liver:
“Liver function: Hemostasis glucose, protein, fat, cholesterol, hormones, vitamins, particularly fat-soluble vitamins (ADEK)
Protein synthesis, including coagulation factors, bile acids, heparin, somatomedins stimulate growth hormone, cholesterol and acute phase proteins.
STORAGEè vitamins, glycogen, cholesterol. Iron, copper, fat.
The excretion of cholesterol, bile acids, phopholipds, bilurobin, drugs, toxins such as heavy metals, hormones.
FILTERING toxins, nutrients, Iga, drugs, damage to dead cells in the circulatory system.
Iga IMMUNEè filter separates the cells in the gut of Kupffer (macrophage) antigens. (Liver Foundation, 2002).
“The liver is vulnerable to a variety of neoplastic, metabolic, toxic, microbial, cardiovascular diseases and insults. The main diseases of the liver are viral hepatitis, alcoholic liver disease and hepatocellular carcinoma. Is more frequent liver injury secondary to some of the most common diseases in humans, such as cardiac decompensation, disseminated cancer, and extrahepatic function. The morphological changes in liver following:
Etiology of liver disease.
“There are the following main causes of liver disease, hepatitis A, B, C, D, E. Epstein-Barvirus, cytomegalovirus virus, yellow fever. Non-viral: Leptospira, Toxoplasma Gendi, fever Q aflatoxin venomous carbantetrachloride, mushrooms, medicinal paracetamol, halothane, alcohol, pergnancy, shock, Wilson’s disease.
Symptoms:
Symptoms: anorexia, malaise, fever, jaundice, right abdomenal pain, hepatomegaly, gynicomastacia, pruritus, hematamesis, confusion,
SIGNS: jaundice, hepatomegaly, pale stools, dark urine, Palmer erythrema, clubbing, jaundice, spleenomegaly testicular atrophy, gynecomastia, with other complications, colateralveins peripheral edema, ascites. “(Davidson 2004)
JOINT LABS: Tests for liver diseases:
“The diagnosis of liver disease depends on a combination of history, physical examination, testing and possibly labortary radiological studies and biopsy.
Method;
One hundred patients with chronic liver disease, 35 patients were included in the study protocol, according to the agreement after it inspects the study period was between 2005-2006, NonHCV, HBV, cirrhosis of the liver disease was admitted Muammad Medical College Hospital,
The aim and task Othis STUDY:
To assess the causes of liver disease, virus, because there were liver function in HCV and HBV deterioate was a common phrase in our community. Undoubtedly, it was still a great danger to our people.
RESULTS:
These results were obtained with the help of SPSS, with frequencies of different groups were Follw descriptor analysis:
The research presented in the graph average
Summary of the study and Corelli in each group were very good at analyzing.
Biostatistics ANALYSIS:
Frequencies:
Frequencies:
Correlation
Correlation
Descriptive Statistics
Descriptive Statistics
Mean
Std Dev
N
Number of patients
41. 1100
12. 10467
100
Number of patients with liver cirrhosis
40. 6000
11. 50499
35
Overall, male patients
29. 8000
5. 62139
15
Overall, patients
48. 7000
7. 24097
20
Correlation
Correlation
Number of patients
Number of patients with liver cirrhosis
Overall, male patients
Overall, patients
Number of patients
Pearson correlation
1
1. 000 (**)
. 998 (**)
. 526 (*)
Sig (2-tailed)
.
. 000
. 000
. 017
N
100
35
15
20
Number of patients with liver cirrhosis
Pearson correlation
1. 000 (**)
1
1. 000 (**)
. 525 (*)
Sig (2-tailed)
. 000
.
.
. 018
N
35
35
15
20
Overall, male patients
Pearson correlation
. 998 (**)
1. 000 (**)
1
. 883 (**)
Sig (2-tailed)
. 000
.
.
. 000
N
15
15
15
15
Overall, patients
Pearson correlation
. 526 (*)
. 525 (*)
. 883 (**)
1
Sig (2-tailed)
. 017
. 018
. 000
.
N
20
20
15
20
** Correlation is significant at 0. 01-level (2-tailed).
* Correlation is significant at 0. 05-level (2-tailed).
DISCUSSION:
In this prospective study, there were a few things to keep in mind that what women are causes of liver disease most affected male relative. This study showed, more women who interpret graphs and tables.
Chronic liver disease is characterized by progressive destruction of overtime liver tissue. It’s Killer seventh largest in the United States, according to the National Institute of Diabetes and Digestive and Kidney Diseases becaudse chronic liver damage, scar tissue gradually replaces normal functioning liver, because the normal liver is lost, nutrients, hormones, drugs and poisons, not be treated effectively by the liver. In addition, production of proteins and other substances produced by the liver are inhibited.
“Obesity is not associated with nonalcohlic foie gras, but also negatively affects the progression of other liver diseases. Special measures should be directly linked to reducing the consumption of nutrient-poor and concentrate foods rich in sodium, aswellastomembersof high fat sources of meat protein (kimech et al 2008)
“Our study matched with the study of Chareon Klad et al (2004), in which they define the objectives, the prevalence of NASH alcohalic among Thai patients with HBV, HCV, chronic hepatitis. Forty-six patients with negative markers for viral hepatitis B – and hepatitis C virus and consumption alcohalic were not included. only in our study, we recruited patients with cirrhosis of the liver 100liver, we are not elected and not alcohalic HBV, HCV. They informed consent for liver biopsy and blood collected for identification of the etiology of chronic hepatitis was made. Thai patients wth alcolici not with HBV, HCV, hepatitis chronic obesity, diabetes and dyslipidemia (kladchareonN, et al 2004)
“This game trial with the study Omagrik et al 1996, they discovered the hepatitis C virus (HCV) is a diagnosis of type C chronic liver disease is not diagnosed with the past through of non-A-B was activated chronic liver disease. Although most cases were associated with chronic liver disease from hepatitis B, C, there is no stillcases B, C, disease Chronic liver. Forty-two patients with chronic liver disease and who were seronegative for hepatitis B, Cweri followed in the study for the treatment. The annual incidence of hepatocellular carcinoma on the liver. 9 3 cirrohosis% and 3. 9% of chronic hepatitis. This shows that their sample population, a number of patients with type B TypC or other etiologic agents. Our study showed that detialed and contained more specific tests for detection of HBV should andHCV Maing before diagnosis o non-B, Nonce chronic liver disease should be considered that there must Revial unknown etiological agents.
Literature:
Filed Under: Health and Ill
