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How to get better health.Chronic Scleroderma
What is Scleroderma? – Scleroderma is a chronic disease characterized by excessive deposits of collagen. In order to better understand Scleroderma it helps if you have some understanding as to what collagen is.
What is Collagen? – Collagen is a fibrous protein that occurrsn bone, cartilage and connective tissue. It is a major structural protein that forms molecular cables to strengthen the tendons and vast, resilient sheets that support the skin and internal organs. There is no organ or tissue which does not have collagen. Collagen acts as the important support structure in tissues around which cells live and function. Elements of our body such as bones and teeth are made by adding mineral crystals to collagen.
Scleroderma directly affects the skin, and in sometimes in more severe cases, it can affect the blood vessels and internal organs of the body. The most visible scleroderma symptom is the hardening of skin and associated scarring that goes along with it. This hardened skin will normally appear reddish or scaly in appearance. Often times this will allow blood vessels to be more visible.
The most serious aspect of the disease to take into account are: The total area that is covered, and the the level of internal involvement that is taking place. These are important to consider because a patient that only has minor coverage is much less likely to have damange to internal organs and tissues as someone with larger coverage.
Almost certainly, in cases where an entire limb is affected, future use of that limb will be jeopardized. If the coverage is over the torse, the heart and lungs will be affected which is more severe, than lets say an arm. Often times, internal scarring will occur which is more complicated and cannot simply be seen by the naked eye.
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Compound from Medicinal Herb Thwarts Turncoat Immune Cells
A small molecule better known for its anti-malarial properties can block the birth of the immune cells involved in autoimmune diseases without blocking crucial infection-fighting cells, report Harvard Medical and Dental School researchers. The findings in the June 5 Science suggest a potentially new therapeutic approach for some autoimmune diseases.
The molecule, called halofuginone, is a synthetic analog made from Febrifugine, and the Chinese herb Chang Shan is the organic source for Febrifugine. The researcher have identified the selective effects of halofuginone on tissue repair—healing wounds while preventing scar tissue formation.
In the body, one common precursor T cell can give rise to both tissue-protective T regulatory, or Treg, cells and the inflammatory T cell type known as T helper 17, or Th17, cells, which play a prominent role in many autoimmune-related disorders, such as scleroderma, multiple sclerosis, inflammatory bowel disease, eczema and psoriasis, rheumatoid arthritis and type 1 diabetes.
Th17 cells were discovered about three years ago by several groups, including another team at HMS. (See Focus, June 9, 2006). “Halofuginone may herald a revolution in the treatment of certain types of autoimmune and inflammatory diseases,” Rao says in a news release.
Chan Shan is derived from roots of a plant in the hydrangea family, Dichroa febrifuga, or blue evergreen hydrangea, which grows in Asia and is used in Chinese herbal medicine. The herb Chang Shan has been used in Chinese medicine for 2000 years and now may play unique role in western medicine.